ea0020p464 | Obesity and Metabolism | ECE2009
Andres Janin
, Biedasek Katrin
, Goegebakan Ozlem
, Mai Knut
, Pfeiffer Andreas
, Spranger Joachim
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by K-cells of proximal small intestine that is secreted postprandial in response to glucose and fat ingestion. Its effect is mediated through a GIP receptor (GIPR) which is widely expressed in different tissues, e.g. pancreatic islets, adipose tissue, skeletal muscle, adrenal cortex, heart, pituitary and in some regions of the brain. However, only the effect of GIP in pancreatic beta-cells is we...